EPO and periventricular nodular heterotopia: Interestingly, and contrary to the transient alteration of Wnt signaling (Bocchi et al., 2017) causing migration delays, the reversible downregulation of intrinsic EPO signaling also led to a permanent misplacement of neuronal progenitors, similar to the ones observed in some pathological conditions, such as periventricular heterotopia, that have been linked with epilepsy as well as mental retardation later in life (Sarkisian et al., 2008).