IL6 and neoplasm: In this study, we also provided evidence that IL-6 and IL-21, cytokines that are increased in the WM tumor microenvironment and contribute to the pathobiology of the disease [21,22], increase glutathione and glutaminase levels in addition to elevating gene expression of ASCT2, SLC7A11 and 4F2HC, the amino acid transporters located on the cell membrane.