In this study, we also provided evidence that IL-6 and IL-21, cytokines that are increased in the WM tumor microenvironment and contribute to the pathobiology of the disease [21,22], increase glutathione and glutaminase levels in addition to elevating gene expression of ASCT2, SLC7A11 and 4F2HC, the amino acid transporters located on the cell membrane. This evidence concerns the gene IL21 and neoplasm.