CD4 and colorectal carcinoma: The positive association of the frequency of PD-1+CD4+ T cells in CN-9 with overall survival is visible in Figure 6J, and this count can be used to stratify patients, as shown in Figure 6K. These findings could imply that specific events occurring in CN-9, related to production, maintenance, or function of PD-1+CD4+ T cells, could contribute to the antitumoral immune response in CRC.