Genome-wide association studies have also identified PD risk variants in three additional lysosomal genes (GUSB, GRN, and NEU1) [56], and cell-type specific enrichment of lysosomal genes have demonstrated associations to PD heritability when selecting for astrocytic, microglial and oligodendroglial subtypes [36]. The gene discussed is GUSB; the disease is Parkinson disease.