On the contrary, we did not observe any reduction of soluble and oligomeric species in the JNPL3 mice, and detected instead an increase of 2 phospho-tau epitopes in the hindbrain: we have no clear explanation at this point for the increase of soluble pSer202 (early p-tau epitope in AD) and pSer396/404 (late p-tau epitope in AD) tau in the JNPL3 HB, which is opposite to the other findings. Here, MAPT is linked to Alzheimer disease.