CD274 and neoplasm: Conversely, there was a statistically significant underexpression of PD-L1 and CD8 in the tumor tissues than in corresponding normal liver tissues (CD8: 21.86 vs. 81.61 per mm2, P < 0.001; PD-L1:31.60 vs. 329.12 per mm2, P < 0.001; Fig. 3h, i).