Furthermore, the numbers of LAG-3+cells and CD8+ T cells were both greater in PD-L1 TC+ (LAG-3: P = 0.024; CD8: P < 0.001; Fig. 2k and m) and positive PD-L1 expression on immune cells (PD-L1 IC+) cases (LAG-3: P = 0.015; CD8: P < 0.001; Fig. 3l, n) than negative PD-L1 expression on tumor cells (PD-L1 TC−) and negative PD-L1 expression on immune cells (PD-L1 IC−) cases respectively. The gene discussed is CD274; the disease is neoplasm.