We predicted that over-expressed GEMs with hypomethylation at promoters in HRD-D1 were involved in ribosome biosynthesis, while suppressed GEMs containing hypermethylation at the gene body were involved in PI3K-Akt or Rap1 signaling pathways, cell adhesion molecule regulation, or infection related responses (Supplementary Table17). Here, AKT1 is linked to infection.