Shahi et al. [13] first used serum D-dimer (850 ng/mL) for the diagnosis of PJI, showing a higher sensitivity and specificity than ESR and CRP (sensitivity: 89% vs. 73% and 79%; specificity: 93% vs. 78% and 80%, respectively), even when evaluating the combined sensitivity and specificity of ESR and CRP. The gene discussed is ESR1; the disease is juvenile polyposis syndrome.