Given that the OM is where the complement system initiate its activation, the compromised OM integrity and increased OM permeability caused by cjrABC-senB expression may increase the accessibility of bacterial targets of serum IgG and properdin, enabling higher levels of IgG and properdin binding on bacterial surface and thus triggering higher levels of antibody-dependent CP activation and AP activation. Here, DHCR7-DT is linked to ocular melanoma.