TOX and central nervous system cancer: TOX expression was negatively associated with inflammatory activity signatures including HCK, LCK, MHC-I, MHC-II, STAT1, and interferon metagenes, but positively associated with the IgG metagene in pan-glioma analysis, LGG alone, and GBM alone (Fig. 6a–c; Fig. Additional file 1: S1D–G).