In addition, the pan-glioma analysis indicated that TOX had a negative association with T cell migration, negative T cell selection, regulation of T cell cytokine production, natural killer cell mediated immunity, positive regulation of T cell apoptotic process, B cell mediated immunity, lymphocyte migration, and lymphocyte chemotaxis, which further confirmed the lymphocyte-suppressing role of TOX in LGGs. This evidence concerns the gene TOX and central nervous system cancer.