IDH1 and central nervous system cancer: The ROC curve further suggested that TOX could be a valuable predictor for IDH mutation across glioma types, in LGG cases, and in GBM cases respectively (AUC value = 0.878, P < 0.001; value = 0.841, P < 0.001; value = 0.814, P < 0.001, respectively Fig. 1d).