It is hypothesized that cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status predict and mediate the individual response to integrated EMDR-DBT and EMDR-only, in adults with PTSD and comorbid (sub)clinical BPD. This evidence concerns the gene FKBP5 and post-traumatic stress disorder.