Obesity has been associated with frailty (Blaum, Xue, Michelon, Semba, & Fried, 2005), and earlier studies also have shown higher levels of leptin to be associated with frailty (Lana, Valdés‐Bécares, Buño, Rodríguez‐Artalejo, & Lopez‐Garcia, 2017). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.