We explored 16 different query topic categories (e.g., ‘Disease and Pathway’, Q7), then we chose example topic for each category (e.g., ‘Breast Cancer, MAPK/ERK pathway’), and finally the terms for each query topic that are combined into a machine readable query written as a logical expression (e.g., ‘breast cancer’ AND (‘Erk pathway’ OR ‘MAPK pathway’ OR ‘Ras pathway’). The gene discussed is MAPK1; the disease is breast cancer.