BRAF and melanoma: At the same time, several studies demonstrated that BRAF inhibitors can impact on immune responses in a direct (e.g., increase of intratumour infiltrating lymphocytes – TILs) and an indirect (increase of melanoma antigens expression) way suggesting a strong rationale of combining these two therapeutic strategies (Boni et al., 2010; Khalili et al., 2012; Koya et al., 2012; Frederick et al., 2013; Sapkota et al., 2013; Kakavand et al., 2015).