Therefore, the deficiency of AMACR or protein inactivation causes neurological disorders (Ferdinandusse et al., 2000a; McLean et al., 2002; Thompson et al., 2008) due to the accumulation of branched-chain fatty acids and is also associated with various peroxisome disorders (Assoum et al., 2010; Dick et al., 2011). The gene discussed is AMACR; the disease is nervous system disorder.