Given the implications of integrin αvβ3 in bone metastasis of various epithelial cancers (Kwakwa and Sterling, 2017), above-mentioned role of Slug in the integrin αvβ3+ breast CSCs that do express E-cadherin (Sun et al., 2018), and elevated E-cadherin expression in BC bone metastases (Saha et al., 2007; Matteucci et al., 2013), we hypothesize that E-cadherin expressing αvβ3+/Slug+ stem-like cells could play a significant role in breast cancer bone metastasis. The gene discussed is SNAI2; the disease is breast carcinoma.