As hybrid E/M phenotypes in circulating tumor cells (CTCs) reveal strong association with tumor-initiation potential and metastasis (Fabisiewicz et al., 2020), Slug+/E-cadherin+ cells are likely contributors to disseminating CTCs as well, perhaps in part through inhibition of anoikis or E-cadherin's potential to support stemness promoting signaling pathways. This evidence concerns the gene SNAI2 and neoplasm.