Furthermore, Slug contributes to treatment resistance of luminal cancers in part through promoting a phenotypic shift to a basal phenotype such as in HER2+ cells (Oliveras-Ferraros et al., 2012) and ER+ cells (Tsou et al., 2015; Geng et al., 2016; Alves et al., 2018). The gene discussed is SNAI2; the disease is cancer.