The co-occurrence of Slug and E-cadherin may be particularly relevant for hybrid EMT and cellular plasticity, which are being recognized as important factors in cancer progression (Jolly et al., 2018; Aiello and Kang, 2019; Gupta et al., 2019), along with the role of E-cadherin in not only the establishment of metastases but also the process of dissemination (Rodriguez et al., 2012; Padmanaban et al., 2019; Voglstaetter et al., 2019). The gene discussed is CDH1; the disease is cancer.