NFKB1 and Hepatic fibrosis: In addition, in vitro studies ascribe a pro-fibrogenic role for TNF on HSCs, as it promotes myofibroblast survival and activation through NFκB activation, while iRhom2-mediated inhibition of TNFR signaling protects against liver fibrosis (Tarrats et al., 2011; Pradere et al., 2013; Bonnardel et al., 2019; Sundaram et al., 2019).