Recently, Biffi and Tuveson (2020) highlighted the importance of IL-1 signaling in shaping CAF functions in PDAC, by showing that tumor-derived IL-1α antagonizes TGFβ signaling and stimulates the production of a cytokine cascade, including LIF, IL-6 and CXCL8 (Biffi et al., 2019). This evidence concerns the gene IL1A and neoplasm.