Univariate and multivariate Cox regression analyses were conducted on the TCGA discovery and the ICGC validation cohorts to evaluate the 10-gene signature-defined risk group as well as clinicopathological variables such as age, gender, BMI, AFP, inflammation, residual tumor, vascular tumor invasion, tumor grade, tumor stage, and TMB as independent prognosis predictors. The gene discussed is AFP; the disease is neoplasm.