Xu et al. (43) demonstrated that when ECE-1 is overexpressed in head and neck squamous cell carcinoma (HNSCC), poor tumor differentiation is associated with worse prognosis; however, in our series, patients with poorly differentiated disease did not experience significantly worse survival rates than patients with well-differentiated lesions (Table 7). The gene discussed is ECE1; the disease is head and neck squamous cell carcinoma.