HUWE1 and neoplasm: For example, MAGEA3/6, a Type I MAGE regulates degradation of AMPK, a master metabolic regulator and tumor-suppressor [5], and activation of cancer-specific MAGEA11-HUWE1 ligase complex leads to alternate polyadenylation of core oncogenic and tumor suppressor transcripts [6], whereas MAGEL2, which is a type II MAGE, regulates protein trafficking by ubiquitination of WASH, a known mediator of the retromer complex [7, 8].