RUNX3 and hereditary clear cell renal cell carcinoma: The KEGG and REACTOME pathway analysis from ClueGO showed that many DEGs were significantly enriched in cardiac muscle contraction (KEGG: 04260), regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPAR alpha) (R-HAS: 400206), transcriptional regulation by RUNX3 (R-HAS: 8878159), ubiquitin-mediated proteolysis (KEGG: 04120), renal cell carcinoma (KEGG: 05211), MyD88: MAL (TIRAP) cascade initiated on plasma membrane (R-HAS: 166058), and IRE1 alpha-activated chaperones (R-HAS: 381070) (Figure 8).