BCL2L1 and cancer: For instance, E7107 (pladienolide B) is a splicing modulator whose preferential cytotoxicity is positively influenced by some antiapoptotic BCL2 family genes, such as BCL2A1, BCL2L2 and MCL1. Furthermore, Aird et al. have reported that combinations of E7107 and BCLxL (BCL2L1-encoded) inhibitors enhance cytotoxicity in cancer cells (Aird et al., 2019).