RBMS1 and cardiovascular disorder: For example, its linear isoform can regulate the c-myc-enhancer-binding factor RBMS1 (Hubberten et al., 2018), while its circular isoform is confirmed to be an important AS regulator that causes skipping of exons (Holdt et al., 2016) and are mainly found in cardiovascular disease (Burd et al., 2010; Sarkar et al., 2017).