Transcriptome analysis of FcRL4+ B-cells from parotid glands of pSS patients (16) revealed that these FcRL4+ B-cells show similarities in gene expression profile to chronically activated CD11c+T-bet+ memory B-cells, which were shown to be involved in the pathogenesis of systemic lupus erythematosus (17, 18). This evidence concerns the gene FCRL4 and systemic lupus erythematosus.