All had lung cancer (small cell lung cancer [SCLC] in three), three with paraneoplastic cerebellar degeneration (PCD) and SOX1, CV2 (CRMP5) and Yo (PCA1) antibodies, and 1 with Lambert Eaton myasthenic syndrome and SOX1 antibodies. This evidence concerns the gene CDR2 and Lambert-Eaton myasthenic syndrome.