EGFR and neoplasm: In fact, immunosuppressive effects of EGFR mutations shape both composition and function of TME by interfering with several intracellular pathways and modulating immune accessory cells such as tumor-infiltrating lymphocytes (TILs), natural killer (NK) cells, T-regulatory cells (Tregs), myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), involved in the increased release of immunoregulatory soluble factors such as cytokines and exosomes, as summarized in Table 2 (47, 48).