Having received anti-TB treatment before  HIV co-infection irrespective of CD4 count  TST (Tuberculin Test) in the last 3 months  Immunosuppressive treatment (Prednisone > 10 mg/day or equivalent; TNF blockers; cancer chemotherapy). Inhaled corticosteroids (At least during the previous month).  End Stage Renal Disease Diabetes  Alcoholism (as confirmed by the attending physician)  Patients with autoimmune disorders or any other immunosuppressive state (as confirmed by the attending physician)  Pregnant women  Unwilling to participate  Being under 18 years old*. This evidence concerns the gene TNF and chronic kidney disease.