CTLA4 and ovarian carcinoma: In ovarian carcinoma, signaling pathways mediated by the interactions of CTLA-4 with CD80 and PD-1 with PD-L1 are negatively regulated by mi-R424(322) (111), suggesting the importance of mi-R424 in the downregulating of CTLA-4 and PD-1 signaling pathways.