Alternatively, the use of ICIs targeting PD-1/PD-L1 axis in patients with acquired resistance (97, 100) due to aberrant expressions of HAT1 and PD-L1 (99) could be beneficial in maximizing the anti-tumor immune response, enhancing the sensitivity to ICI, and overcoming resistance (Figure 3B, ii). The gene discussed is CD274; the disease is neoplasm.