Here, in MM patients with Amp1q21, gC1qR was found to promote MM cell line survival by suppressing the MM-inhibiting role of C1q and contributing to the stabilization of the CDC28 protein kinase regulatory subunit 1B (CKS1B) mRNA through insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3). Here, IGF2BP3 is linked to Miyoshi myopathy.