The membrane VEGFR distributions have also been examined in the endothelium from healthy mouse skeletal muscle and tumor xenograft models, where endothelial cells stably present low membrane VEGFR2 (<1700 VEGFR2/cell) across normal and tumor xenografts (Imoukhuede and Popel, 2012, 2014; Chen et al., 2018) despite VEGF-A:VEGFR2 binding being the primary pro-angiogenic signaling pathway (Olsson et al., 2006). Here, VEGFA is linked to neoplasm.