Here, we highlight three VEGF-A165b properties that are implicated in obesity: (1) VEGFR binding: VEGF-A165b competes with VEGF-A165a for VEGFR binding in pathological conditions (Woolard et al., 2004; Mamer and Wittenkeller, 2016a, b; Clegg and Mac Gabhann, 2017). The gene discussed is VEGFA; the disease is obesity due to melanocortin 4 receptor deficiency.