According to the researches above, HIF-1α is closely correlated with the developing process of several cardiovascular diseases, such as endothelial dysfunction, smooth muscle proliferation, inflammation, and angiogenesis through the transcription of vascular endothelial growth factor (VEGF), erythropoietin (EPO), CXCL1, etc (Figure 1). This evidence concerns the gene EPO and cardiovascular disorder.