PPARGC1A and peritonitis: Ding et al. (2017) reported that knockdown of SIRT3 inhibited osteogenic differentiation via its role in decreasing the stability of PGC-1α by increasing its acetylation and via downregulated expression of Mn-SOD; this results in elevated levels of ROS and reduced mitochondrial biogenesis and function. Cherry et al. (2014) reported that PGC-1α promotes mitochondrial biogenesis and induces expression of antioxidative enzyme, most notably Nrf2-mediated Mn-SOD expression in the liver of mice of Staphylococcus aureus-induced peritonitis.