MTOR and metabolic disease: The present study shows that ethanol time or dose-dependently reduce the mTOR signaling, and which clearly affects protein synthesis, lipid and glucose metabolism (Mao and Zhang, 2018), and thus, lower AMPK activation as well as GLUT4 and CPT1 protein content are associated with lack of mTOR signaling, and these data suggest the lack of CPT1 increases fatty acids accumulation and this effect along with GLUT4 deficiency by EtOH accelerate metabolic disorder for glucose uptake.