Since PPARβ/δ (PPARδ) is the predominant isoform that regulates fatty acid oxidation (Dressel et al., 2003; Tanaka et al., 2003; Wang et al., 2003) and that is essential to maintain a normal level of mitochondria (Koh et al., 2017) and GLUT4 in skeletal muscle (Koh et al., 2019a), we speculated that PPARδ is one of the candidates to improve the metabolism in skeletal muscle against lipid dysregulation due to alcohol abuse. The gene discussed is PPARD; the disease is alcohol abuse.