showed that Rp-cAMPS, a cAMP competitor, rescued Nrf2 activity in CF epithelial cells by shifting the CBP association in favor of Nrf2 (over NF-kB), thus decreasing inflammatory signaling and increasing antioxidant and anti-inflammatory activity (Ziady et al., 2012). In this study HO-1 expression was not tested, however, the rescued Nrf2 activity should result in increased HO-1 expression. The gene discussed is CREBBP; the disease is cystic fibrosis.