HMOX1 and hyperinsulinemic hypoglycemia, familial, 4: Importantly, the phenotypical alterations in the uniquely observed case of human HO-1 deficiency are similar to those in HO-1 KO mice, with severe hemolytic anemia, endothelial degradation, reduced serum bilirubin, renal and hepatic iron accumulation, and a pro-inflammatory phenotype (Yachie et al., 1999).