Especially, to demonstrate the clinical efficacy of AM and NT on pruritus, NGF, Tropomyosin receptor kinase A (TrkA), Raf-1 (Serine/Threonine kinase), MEK (MAPK/ERK kinase), and Extracellular signal-regulated kinases (ERK) pathway and interleukin (IL)-31 were examined. Here, NTRK1 is linked to Pruritus.