A recent study reported that abnormal DNA methylation together with other epigenetic changes can lead to diverse pathologies including altered neurogenesis, abnormal neuronal migration, and aberrant structure of individual cells, and/or large networks in epilepsy (Kobow and Blümcke, 2014), consistent with our results that increased methylation of NR4A1 in TLE patients was associated with impaired brain function and structure in subcortical nuclei, temporal network and cerebellum. The gene discussed is NR4A1; the disease is epilepsy.