Within this scenario, it was also shown that the oligodendrocytic protein myelin-associated oligodendrocyte basic protein (MOBP) was a risk locus for ALS (van Rheenen et al., 2016), and that the expression of the astrocytic protein excitatory amino acid transporter-2 (EAAT2) is reduced and its activity is decreased in the motor cortex and spinal cord of both ALS patients and SOD1G93A transgenic mice (Rothstein et al., 1995, 2005; Ganel et al., 2006; Pardo et al., 2006; Foran et al., 2011; Karki et al., 2015; Lee et al., 2016). The gene discussed is MOBP; the disease is amyotrophic lateral sclerosis.