In the context of ALS, it was shown that numerous miRNAs are upregulated, namely miR-155, miR- 22, miR-125b, miR-146b, and miR-365, in SOD1-G93A mice and in the spinal cord of ALS patients (Butovsky et al., 2012; Koval et al., 2013; Parisi et al., 2013, 2016). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.