At the end of DEL the mild challenges used for IND upregulated mRNA expression of several components of the RAS and PICs and of microglial marker in the brain, whereas central inhibition of AT1-R, mineralocorticoid receptors, and inflammation reversed the changes in gene expression and also prevented the sensitization of ANG II-elicited hypertension seen during EXP. This evidence concerns the gene AGTR1 and Hypertension.