LEP and obesity due to melanocortin 4 receptor deficiency: This notion is supported by recent studies showing that although animals with diet-induced obesity (DIO) can restore body weight, insulin levels and leptin sensitivity to normal after being switched to a normal fat diet, BP, renal sympathetic nerve activity (RSNA) and the activity of central RAS and PICs remain high (Prior et al., 2010; Maric et al., 2014).