DACT1 and hepatocellular carcinoma: DACT1 is a Wnt-pathway inhibitor, it has been reported that miR-324-3p activated Wnt/β-catenin signaling via targeting DACT1 to promote hepatocellular carcinoma growth [15], meanwhile, we predicted the binding sites of miR-324-3p in the 3′ non-coding region(UTR) of DACT1 by targetscan (Fig. 4).