To identify the function of KCNQ1OT1 on cells proliferation, MTT assay was performed in SW480 and LS1034 cells, the results showed that the proliferation abilities of CRC cells were reduced by the transfection of si-KCNQ1OT1 (#1/2) (P < 0.05, Fig. 2b, c). This evidence concerns the gene KCNQ1OT1 and colorectal carcinoma.