Data suggested that after CTNND1 highly expressed, the SW480 and LS1034 cells proliferation rate (P < 0.05, Fig. 6b, c), migratory and invasive ability were increased (P < 0.05, Fig. 6e, f), however, apoptosis ability was hindered (P < 0.05, Fig. 6d).These results indicate that CTNND1 may work as a tumor promoter in CRC cells. This evidence concerns the gene CTNND1 and colorectal carcinoma.