After SW480 and LS1034 cells were transfected with miR-329-3p mimic, we found the protein levels of CyclinD1, Bcl-2, MMP9 were decreased, while the protein levels of E-cadherin, Cleaved-casp-3 were increased, while these tendencies were overturned by co-transfection of pcDNA-CTNND1 (P < 0.05, Fig. 6g, h). We found that CTNND1 overexpression decreased the level of epithelial marker (E-cadherin), this phenomenon indicated that CTNND1 plays a key role in regulating EMT plasticity of CRC cells. The gene discussed is CCND1; the disease is colorectal carcinoma.