Meanwhile, we conducted rescue assays to manifest that regulation of KCNQ1OT1 on proliferation, apoptosis, migration, and invasion was mediated by CTNND1, further validating that KCNQ1OT1 knockdown represses CRC progression via the miR-329-3p/CTNND1 axis in vitro. Here, CTNND1 is linked to colorectal carcinoma.