Noticeably, the suni + sh-HOTAIR group had decreased tumor size (Fig. 6a), reduced HOTAIR (Fig. 6b), LC3-II/LC3-I ratio (Fig. 6c), and Ki67 positive rate (Fig. 6d) as well as increased p62 expression (Fig. 6c) in comparison to the suni + sh-NC group (P < 0.05), illustrating that knockdown of HOTAIR in vivo could reduce sunitinib resistance in RC cells. Here, HOTAIR is linked to neoplasm.