In addition, the alternative splicing regulated by SRSF1 in tumor cells also includes the proto-oncogenes MYBL2 (B-myb), MYB (C-myb) 64, the tumor suppressor gene BRCA1 65, and the apoptosis-related gene Mcl1 66, Vascular endothelial growth factor VEGF 67, cell migration-related gene MST1R (Ron) 49, etc. In addition, Kurokawa K et al. found that SRSF3 can regulate apoptosis by affecting alternative splicing of HIPK2 (homeodomain-interacting protein kinase-2) and produced a HIPK2 Δe8 isoform in colon cancer cells 68. Here, HIPK2 is linked to malignant colon neoplasm.