In addition, some other agents such as hemin-carried drugs based on lipid 82, NADPH oxidase 4 (Nox4) 83, hyaluronic acid oligosaccharides (o-HA) 84, played possible beneficial roles in restoring cardiac function post MI by targeting cardiac macrophages and skewing them towards an M2 anti-inflammatory phenotype, which provided a novel strategy to regulate inflammation, reduce adverse remodeling, and improve the contractile function of infarcted hearts. The gene discussed is NOX4; the disease is myocardial infarction.