In fact, IL-22 plays a dual role in the occurrence of HCC; On the one hand, it protects the liver from damage by contributing to the survival of normal hepatic cells; On the other hand, IL-22 can promotes the survival of damaged liver cells (which can be the precursor of hepatocellular carcinoma), ultimately leading to the occurrence of hepatocellular carcinoma 3. This evidence concerns the gene IL22 and hepatocellular carcinoma.