IL-22, which acts on a variety of tissues and organs such as the intestines, lungs, liver, kidney, thymus, pancreas and skin, has a lot of functions; It is worth mentioning that IL-22 acts as either a anti-inflammatory or proinflammatory cytokine in many disease models such as psoriasis, ulcerative colitis, systemic lupus erythematosus and other inflammatory diseases 3. Here, IL22 is linked to ulcerative colitis.