IL-22, which acts on a variety of tissues and organs such as the intestines, lungs, liver, kidney, thymus, pancreas and skin, has a lot of functions; It is worth mentioning that IL-22 acts as either a anti-inflammatory or proinflammatory cytokine in many disease models such as psoriasis, ulcerative colitis, systemic lupus erythematosus and other inflammatory diseases 3. This evidence concerns the gene IL22 and systemic lupus erythematosus.