In high fat diet (HFD) fed mice, the neutrophil‐derived reactive oxygen species and activation of stress kinases lead to the hepatic overexpression of C-X-C motif chemokine ligand 1 (CXCL1) and drive the progression of steatosis-to-NASH 25. The gene discussed is CXCL1; the disease is metabolic dysfunction-associated steatohepatitis.