Besides, recent studies reported that IL-8 was required for the expression of cancer stem cell (CSC) properties through protein O-GlcNAcylation promotion, glucose uptake stimulation and glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT) upregulation 99. This evidence concerns the gene CXCL8 and cancer.