TLR4 and colorectal carcinoma: In another trial, the researchers separated 40 patients with CRC into two groups: using open colectomy as group A and using laparoscopic colectomy as group B. The researchers measured IL-6, TLR-2, TNF-α, TLR-4 and high-sensitivity CRP (hsCRP) levels and concluded that laparoscopic colectomy had short-term clinical advantages compared with open colectomy owing to the higher levels of IL-6, TLR-2, TLR-4 and hsCRP in group A than compared to those in group B 143.