Treatment of the colorectal carcinoma cell line SW480 with IL-8 and IL-20 combined was shown to induce the expression of an EMT phenotype, by triggering the PI3K/AKT-ERK1/2 cross-talk signaling pathway, while treatments with IL-8 or IL-20 alone induced only an EMT-like phenotype, which suggested that IL-8 influenced but did not drive CRC metastasis 97. This evidence concerns the gene AKT1 and colorectal carcinoma.