Infected with an IL-22BP overexpression vector in C26 CC cells, the effects of tumour angiogenesis and anti-apoptosis were attenuated, and the expression of p-STAT3, VEGF-A, Bcl-xL and survirin was downregulated, which provided a theoretical basis for the use of IL-22BP in the treatment of CRC patients 120. The gene discussed is IL22RA2; the disease is neoplasm.