Specifically, these cells were also used to explain the experimental phenomena showing that exogenous IL-1α with 5-Fu changed the expression of cell adhesion molecules and that exogenous IL-1α promoted chemosensitivity in both chemosensitive and chemoresistant CRC cell lines, while endogenous IL-1α promoted chemosensitivity only in the chemosensitive HCT116 cells. The gene discussed is IL1A; the disease is colorectal carcinoma.