ZHX2 and hepatocellular carcinoma: The results have proved that miR-3188-KO by CRISPR/Cas9 can significantly increase the expression of zinc fingers and homeoboxes protein 2 (ZHX2), which is a direct target of miR-3188 in HCC cells, thus blocking HBV X protein (HBx)-mediated activation of miR-3188 and Notch signaling pathway 57.