Consistent with results in WT mice, CHK-265 reduced viremia in Rag1-/- and Ifnar1-/- mice for the first 24 hours post-infection (hpi), and by 48 hpi, both Rag1-/- and Ifnar1-/- mice had high viremia comparable to that in isotype mAb-treated mice (Fig 4A and 4B). The gene discussed is RAG1; the disease is infection.