In 323 consecutive patients with CAD and mild to intermediate coronary artery stenosis, iFR-FFR mismatch was observed to a certain extent, and the predictors of iFR, which included clinical factors such as gender, diabetes mellitus, hs-CRP level, renal function, and aortic stenosis, were different from those of FFR. The gene discussed is CRP; the disease is coronary artery disorder.