Specifically, LHA and HCC significantly upregulated the expression of desmin by 2.2 and 2.3 fold, respectively, as compared to TNF-α, while for myogenin expression, both LHA and HCC increased its level by 1.6 and 1.75 fold, respectively (Fig 6B) (p<0.01). This evidence concerns the gene DES and hepatocellular carcinoma.